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Gene expression profiles obtained from laser-microdissected human choroid plexus papilloma cells

ABSTRACT: Gene expression profiles generated from human tumor cells laser-microdissected from surgical samples of seven choroid plexus papillomas (Grade I WHO) as eight samples of epithelial cells lasermicrodissected from normal choroid plexus obtained at autopsy. Choroid plexus tumors are rare pediatric brain tumors derrived from the choroid plexus epithelium. Gene expression profiles of lasermicrodissected tumor cells from 7 individual choroid plexus tumor samples obtained at surgery were compared to gene expression profiles from non-neoplastic choroid plexus epithelial cells lasermicrodissected from normal non-neoplastic choroid plexus obtained at autopsy (Am J Surg Pathol. 2006 Jan;30(1):66-74.) in order to identfy genes differentially expressed in choroid plexus tumor cells.

ORGANISM(S): Homo sapiens  

SUBMITTER: Martin Hasselblatt   Heike Stegemann 

PROVIDER: E-GEOD-14098 | ArrayExpress | 2009-02-01



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TWIST-1 is overexpressed in neoplastic choroid plexus epithelial cells and promotes proliferation and invasion.

Hasselblatt Martin M   Mertsch Sonja S   Koos Björn B   Riesmeier Barbara B   Stegemann Heike H   Jeibmann Astrid A   Tomm Manuel M   Schmitz Nicole N   Wrede Brigitte B   Wolff Johannes E JE   Zheng Wei W   Paulus Werner W  

Cancer research 20090310 6

The pathogenesis of choroid plexus papillomas, intraventricular papillary neoplasms most often occurring sporadically in children and young adults, remains poorly understood. To identify pathways operative in the development of choroid plexus papillomas, gene expression profiles obtained from laser-microdissected human choroid plexus papilloma cells (n = 7) were compared with that of normal choroid plexus epithelial cells laser microdissected from autopsy tissue (n = 8). On DNA microarray data a  ...[more]

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