Transcriptomics

Dataset Information

240

Profiling the target genes for LSD1, MTA1, MTA2, and MTA3 in MCF-7


ABSTRACT: Using ChIP-DSL technology from AVIVA SYSTEMS BIOLOGY to find out the whole genome targets for LSD1, MTA1, MTA2, and MTA3 We analyzed arrays using antibodies against LSD1, MTA1, MTA2, or MTA3 and negative control to acquire the enriched ratio of each gene.

ORGANISM(S): Homo sapiens  

SUBMITTER: Yongfeng Shang  

PROVIDER: E-GEOD-14260 | ArrayExpress | 2009-08-21

SECONDARY ACCESSION(S): GSE14260PRJNA111219

REPOSITORIES: GEO, ArrayExpress

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Publications


Lysine-specific demethylase 1 (LSD1) exerts pathway-specific activity in animal development and has been linked to several high-risk cancers. Here, we report that LSD1 is an integral component of the Mi-2/nucleosome remodeling and deacetylase (NuRD) complex. Transcriptional target analysis revealed that the LSD1/NuRD complexes regulate several cellular signaling pathways including TGFbeta1 signaling pathway that are critically involved in cell proliferation, survival, and epithelial-to-mesenchym  ...[more]

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