Transcriptomics

Dataset Information

13

Transcription profiling by array of human CD4+ T cells from HIV-resistant and HIV-susceptible individuals


ABSTRACT: Understanding why some individual resist HIV-1 infection despite continued exposure is an important goal for vaccine development. We compared CD4+ T cell gene expression at baseline in HIV-1 resistant commercial sex-workers from Nairobi, Kenya to HIV-1 high-risk negative (non-resistant) commercial sex-workers using gene expression arrays Experiment Overall Design: CD4+ T cells from both HIV resistant and HIV low-risk negative individuals were isolated from PBMC after 24 hours of culture by negative selection. Total RNA was isolated and gene expression compared using Affymetrix total genome arrays.

REANALYSED by: E-GEOD-14278

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Paul McLaren  

PROVIDER: E-GEOD-14278 | ArrayExpress | 2009-01-17

SECONDARY ACCESSION(S): GSE14278PRJNA114563

REPOSITORIES: GEO, ArrayExpress

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Publications

HIV‐exposed seronegative commercial sex workers show a quiescent phenotype in the CD4+ T cell compartment and reduced expression of HIV‐dependent host factors.

McLaren Paul J PJ   Ball T Blake TB   Wachihi Charles C   Jaoko Walter W   Kelvin David J DJ   Danesh Ali A   Kimani Joshua J   Plummer Francis A FA   Fowke Keith R KR  

The Journal of infectious diseases 20101101


Studies of human immunodeficiency virus (HIV)-exposed seronegative individuals are crucial to inform vaccine design. In the present study we demonstrated that HIV-exposed seronegative commercial sex workers produce lower levels of proinflammatory cytokines at baseline than HIV-negative control subjects. We also showed that CD4+ T cells of HIV-exposed seronegative commercial sex workers have a characteristically lower level of gene expression that can be seen in differentially expressed genes and  ...[more]

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