Dataset Information


Regulatory and conventional T-cells

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE14232: Transcriptome analysis of freshly sorted and expanded regulatory and conventional T cells GSE14233: Detection of differentially methylated regions in CD4+CD25+CD45RA+ regulatory T-cells and conventional CD4+CD25- T-cells GSE14234: Histone H3 Lysine 4 mono-, di- and trimethyl and CTCF in CD4+CD25+CD45RA+ regulatory and conventional CD4+CD25- T-cells Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Christian Schmidl  

PROVIDER: E-GEOD-14281 | ArrayExpress | 2010-05-19



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Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity.

Schmidl Christian C   Klug Maja M   Boeld Tina J TJ   Andreesen Reinhard R   Hoffmann Petra P   Edinger Matthias M   Rehli Michael M  

Genome research 20090603 7

DNA methylation participates in establishing and maintaining chromatin structures and regulates gene transcription during mammalian development and cellular differentiation. With few exceptions, research thus far has focused on gene promoters, and little is known about the extent, functional relevance, and regulation of cell type-specific DNA methylation at promoter-distal sites. Here, we present a comprehensive analysis of differential DNA methylation in human conventional CD4(+) T cells (Tconv  ...[more]

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