Transcriptomics,Multiomics

Dataset Information

29

Transcription profiling time series of the response of human microglial cells to interferon gamma


ABSTRACT: Microglial cells are resident macrophages in the central nervous system (CNS) and play a pivotal role in the innate and adaptive immune responses against microbial infections. The immune functions of microglia are regulated by a milieu of cytokines including interferon (IFN)-gamma. We here performed a series of experiments to acertain the transcriptional profile of human fetal microglial cells at 1, 6, and 24 h after IFN-gamma treatment. Primary human microglial cells were either untreated or treated with 200u/ml IFN-gamma. Affymetrix U133A chips were utilized. Four different tissue samples (B18, O, W, and Y20) were analyzed at the three time points.

OTHER RELATED OMICS DATASETS IN: PRJNA89967

ORGANISM(S): Homo Sapiens

SUBMITTER: Robert Bryan Rock  

PROVIDER: E-GEOD-1432 | ArrayExpress | 2007-08-03

SECONDARY ACCESSION(S): GDS1036GSE1432PRJNA89967

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-1432.README.txt Txt
E-GEOD-1432.idf.txt Idf
E-GEOD-1432.processed.1.zip Processed
E-GEOD-1432.sdrf.txt Txt
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Publications

Transcriptional response of human microglial cells to interferon-gamma.

Rock RB   Hu S   Deshpande A   Munir S   May BJ   Baker CA   Peterson PK   Kapur V  

Genes and immunity 20051201 8


Microglia, the resident macrophages in the central nervous system (CNS), play a pivotal role in innate and adaptive immune responses in the brain. The immune functions of microglia are regulated by cytokines, including interferon (IFN)-gamma, which is a major mediator of macrophage activation. We describe the transcriptional profile of human fetal microglial cells at 1, 6, and 24 h after IFN-gamma treatment. The results show a change in the expression of 405 genes including transcriptionally ind  ...[more]

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