Transcriptomics,Multiomics

Dataset Information

3

ArrayCGH of human hepatocellular carcinoma (HCC)


ABSTRACT: We used array-based comparative genomic hybridization (arrayCGH) of 76 hepatocellular carcinomas (HCCs) to search for genetically disrupted genes. Seventy-six HCC clinical specimens were analyzed. Genomic DNA of the tumor sample was labeled with Cy5 and reference normal DNA (Promega) was labeled with Cy3.

OTHER RELATED OMICS DATASETS IN: PRJNA111431PRJNA111593

ORGANISM(S): Homo sapiens  

SUBMITTER: Xin Wei Wang   Stephanie Roessler 

PROVIDER: E-GEOD-14322 | ArrayExpress | 2012-01-20

SECONDARY ACCESSION(S): GSE14322PRJNA111431

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-14322.README.txt Txt
E-GEOD-14322.eSet.r Other
E-GEOD-14322.idf.txt Idf
E-GEOD-14322.processed.1.zip Processed
E-GEOD-14322.raw.1.zip Raw
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Publications


<h4>Background & aims</h4>Hepatocellular carcinoma (HCC) is an aggressive malignancy; its mechanisms of development and progression are poorly understood. We used an integrative approach to identify HCC driver genes, defined as genes whose copy numbers associate with gene expression and cancer progression.<h4>Methods</h4>We combined data from high-resolution, array-based comparative genomic hybridization and transcriptome analysis of HCC samples from 76 patients with hepatitis B virus infection  ...[more]

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