Dataset Information


Transcription profiling by array of human multiple myeloma cell lines after treatment with arsenic

ABSTRACT: We used microarrays to examine changes in gene expression in multiple myeloma cell lines following treatment with arsenic trioxide and darinaparsin Experiment Overall Design: Four multiple myeloma cell lines (U266, MM.1s, KMS11, 8226/S) were treated with either arsenic trioxide (ATO) for 6, 24, or 48 hours or darinaparsin (DAR) for 6 or 24 hours; RNA was extracted from treated and control cells for microarray analysis

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Larry Boise  

PROVIDER: E-GEOD-14519 | ArrayExpress | 2009-02-01



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Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line.

Matulis Shannon M SM   Morales Alejo A AA   Yehiayan Lucy L   Croutch Claire C   Gutman Delia D   Cai Yong Y   Lee Kelvin P KP   Boise Lawrence H LH  

Molecular cancer therapeutics 20090505 5

Here, we report on the organic arsenical darinaparsin (ZIO-101, S-dimethylarsino-glutathione) and its anti-myeloma activity compared with inorganic arsenic trioxide. Darinaparsin induced apoptosis in multiple myeloma cell lines in a dose-dependent manner, and the addition of N-acetylcysteine, which increases intracellular glutathione (GSH), blocked cytotoxicity of both darinaparsin and arsenic trioxide. In contrast to arsenic trioxide, intracellular GSH does not appear to be important for darina  ...[more]

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