Transcriptomics

Dataset Information

39

Mucosal gene signatures to predict response to infliximab in patients with ulcerative colitis


ABSTRACT: Infliximab, an anti-TNF-alpha monoclonal antibody, is an effective treatment for ulcerative colitis (UC) with over 60% of patients responding to treatment and up to 30% reaching remission. The mechanism of resistance to anti-TNF-alpha is unknown. This study used colonic mucosal gene expression to provide a predictive response signature for infliximab treatment in UC. Keywords: drug response Twenty-four patients with active UC, refractory to corticosteroids and/or immunosuppression, underwent colonoscopy with biopsies from diseased colon within a week prior to the first intravenous infusion of 5 mg infliximab per kg body weight. Response to infliximab was defined as endoscopic and histologic healing at 4-6 weeks after first infliximab treatment. Six control patients with normal colonoscopy were included. Total RNA was isolated from colonic mucosal biopsies, labelled and hybridized to Affymetrix Human Genome U133 Plus 2.0 Arrays.

REANALYSED by: E-GEOD-14580

OTHER RELATED OMICS DATASETS IN: E-GEOD-12251

ORGANISM(S): Homo sapiens  

SUBMITTER: Karel Geboes   Gert De Hertogh  Frans Schuit  Paul Rutgeerts  Leentje Van Lommel  Kristel Van Steen  Ingrid Arijs 

PROVIDER: E-GEOD-14580 | ArrayExpress | 2010-01-06

SECONDARY ACCESSION(S): GSE14580PRJNA111695

REPOSITORIES: GEO, ArrayExpress

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Publications


BACKGROUND AND AIMS: Infliximab is an effective treatment for ulcerative colitis with over 60% of patients responding to treatment and up to 30% reaching remission. The mechanism of resistance to anti-tumour necrosis factor alpha (anti-TNFalpha) is unknown. This study used colonic mucosal gene expression to provide a predictive response signature for infliximab treatment in ulcerative colitis. METHODS: Two cohorts of patients who received their first treatment with infliximab for refractory ulce  ...[more]

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