Transcriptomics

Dataset Information

27

Transcription profiling of human fetal thymocytes and circulating naive T cells


ABSTRACT: Subpopulations of human fetal thymocyte and circulating naïve T cells were obtained through FACS sorting, including CD3-CD4+CD8- intrathymic T progenitor cells (ITTP), CD3intCD4+CD8+ "double positive" thymocytes (DP), CD3highCD4+CD8- "single positive" thymocytes (SP4), CD3+CD4+CD8-CD45RA+CD62L+ naïve T cells from cord blood (CB4+), and CD3+CD4+CD8-CD45RA+CD62L+ naïve T cells from adult blood (AB4+).

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Myeong S. Lee  

PROVIDER: E-GEOD-1460 | ArrayExpress | 2007-08-06

SECONDARY ACCESSION(S): GDS785GDS786GSE1460PRJNA90033

REPOSITORIES: GEO, ArrayExpress

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Publications

Gene expression profiles during human CD4+ T cell differentiation.

Lee Myeong Sup MS   Hanspers Kristina K   Barker Christopher S CS   Korn Abner P AP   McCune Joseph M JM  

International immunology 20040621 8


To develop a comprehensive catalogue of phenotypic and functional parameters of human CD4(+) T cell differentiation stages, we have performed microarray gene expression profiling on subpopulations of human thymocytes and circulating naive CD4(+) T cells, including CD3(-)CD4(+)CD8(-) intrathymic T progenitor cells, CD3(int)CD4(+)CD8(+) 'double positive' thymocytes, CD3(high)CD4(+)CD8(-) 'single positive' thymocytes, CD3(+)CD4(+)CD8(-) CD45RA(+)CD62L(+) naive T cells from cord blood and CD3(+)CD4(  ...[more]

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