Transcriptomics

Dataset Information

44

Renal Cell Carcinoma: Hypoxia and Endocytosis


ABSTRACT: Hypoxia signature in Clear cell RCC A set of clear cell renal cell carcinomas were examined for the deregulation of hypoxia inducible and endocytosis regulated genes Tumor samples and Normal renal tissue GSE14762.rda contains an R data object

ORGANISM(S): Homo sapiens  

SUBMITTER: Kyle Furge  Karl Dykema 

PROVIDER: E-GEOD-14762 | ArrayExpress | 2009-02-09

SECONDARY ACCESSION(S): GSE14762PRJNA112257

REPOSITORIES: GEO, ArrayExpress

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Publications


Tumor hypoxia is associated with disease progression, resistance to conventional cancer therapies and poor prognosis. Hypoxia, by largely unknown mechanisms, leads to deregulated accumulation of and signaling via receptor tyrosine kinases (RTKs) that are critical for driving oncogenesis. Here, we show that hypoxia or loss of von Hippel-Lindau protein--the principal negative regulator of hypoxia-inducible factor (HIF)--prolongs the activation of epidermal growth factor receptor that is attributab  ...[more]

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