Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Prethish Sreenivas Soji Sebastian Prashanth Kandalla Jyotsna Dhawan Sirisha Cheedipudi Ramkumar Sambasivan Grace K Pavlath
PROVIDER: E-GEOD-14931 | ArrayExpress | 2010-05-22
SECONDARY ACCESSION(S): GSE14931PRJNA111923
REPOSITORIES: GEO, ArrayExpress
Proceedings of the National Academy of Sciences of the United States of America 20090305 12
Most cells in adult tissues are nondividing. In skeletal muscle, differentiated myofibers have exited the cell cycle permanently, whereas satellite stem cells withdraw transiently, returning to active proliferation to repair damaged myofibers. We have examined the epigenetic mechanisms operating in conditional quiescence by analyzing the function of a predicted chromatin regulator mixed lineage leukemia 5 (MLL5) in a culture model of reversible arrest. MLL5 is induced in quiescent myoblasts and ...[more]