Transcriptomics

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Gene expression data from primate postnatal brain development - superior frontal gyrus


ABSTRACT: In development, timing is of the utmost importance, and the timing of various developmental processes are often changed during evolution. During human evolution sexual maturation has been delayed relative to other primates and this may have played a critical role for both the increase of human brain size and the rise of human-specific cognitive traits . We measured the timing of gene expression changes in the superior frontal gyrus region of the brains of humans, chimpanzees, and rhesus macaques throughout postnatal development. Keywords: Age series Human, chimpanzee and rhesus macaque post-mortem brain samples from the superior frontal gyrus region of the prefrontal cortex were collected. The age ranges of the individuals in all three species covered the respective species' postnatal maturation period from infancy to adulthood. RNA extracted from the dissected tissue was hybridized to Affymetrix® Human Gene 1.0 ST arrays.

ORGANISM(S): Troglodytes  

SUBMITTER: Song Guo  Michael Lachmann   Philipp Khaitovich   Yan Zhen   Svante Pääbo   Cynthia S Weickert   Mehmet Somel   Sabine Bahn   Maree J Webster    

PROVIDER: E-GEOD-15163 | ArrayExpress | 2009-03-09

SECONDARY ACCESSION(S): GSE15163PRJNA114937

REPOSITORIES: GEO, ArrayExpress

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In development, timing is of the utmost importance, and the timing of developmental processes often changes as organisms evolve. In human evolution, developmental retardation, or neoteny, has been proposed as a possible mechanism that contributed to the rise of many human-specific features, including an increase in brain size and the emergence of human-specific cognitive traits. We analyzed mRNA expression in the prefrontal cortex of humans, chimpanzees, and rhesus macaques to determine whether  ...[more]

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