Dataset Information


Effects of haloperidol on zebrafish and fathead minnow gene expression

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE14861: Small_fish_comp_tox_ZF_haloperidol_96_h_ovary GSE15115: Small_fish_comp_tox_FHM_haloperidol_96_h_ovary Refer to individual Series

SUBMITTER: Dan Villeneuve  

PROVIDER: E-GEOD-15216 | ArrayExpress | 2010-05-17



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II: Effects of a dopamine receptor antagonist on fathead minnow dominance behavior and ovarian gene expression in the fathead minnow and zebrafish.

Villeneuve Daniel L DL   Garcia-Reyero Natàlia N   Martinović Dalma D   Mueller Nathaniel D ND   Cavallin Jenna E JE   Durhan Elizabeth J EJ   Makynen Elizabeth A EA   Jensen Kathleen M KM   Kahl Michael D MD   Blake Lindsey S LS   Perkins Edward J EJ   Ankley Gerald T GT  

Ecotoxicology and environmental safety 20091107 4

Neurotransmitters such as dopamine play an important role in reproductive behaviors and signaling. Neuroendocrine-active chemicals in the environment have potential to interfere with and/or alter these processes. A companion study with the dopamine 2 receptor antagonist, haloperidol, found no evidence of a direct effect of the chemical on fish reproduction. This study considered haloperidol's potential effects on behavior and ovarian gene expression. Male fathead minnows exposed to 50 microg hal  ...[more]

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