Transcriptomics

Dataset Information

4

Transcription profiling of rat somatic cells from testes treated with hormone


ABSTRACT: Analysis of hormone effects on irradiated LBNF1 rat testes, which contain only somatic cells except for a few type A spermatgogonia. Rats were treated for 2 weeks with either sham treatment (group X), hormonal ablation (GnRH antagonist and the androgen receptor antagonist flutamide, group XAF), testosterone supplementation (GnRH antagonist and testosterone, group XAT), and FSH supplementation ((GnRH antagonist, androgen receptor antagonist, and FSH, group XAFF). Results provide insight into identifying genes in the somatic testis cells regulated by testosterone, LH, or FSH. Experiment Overall Design: 14 Sample replicates of sham treatment, 11 Sample replicates of hormonal ablation, 5 Sample replicates of testosterone supplementation, and 5 Sample replicates of FSH supplementation were studied.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Wei Zhou  

PROVIDER: E-GEOD-15243 | ArrayExpress | 2009-10-10

SECONDARY ACCESSION(S): GSE15243PRJNA116529

REPOSITORIES: GEO, ArrayExpress

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Publications

Changes in gene expression in somatic cells of rat testes resulting from hormonal modulation and radiation-induced germ cell depletion.

Zhou Wei W   Bolden-Tiller Olga U OU   Shetty Gunapala G   Shao Shan H SH   Weng Connie C CC   Pakarinen Pirjo P   Liu Zhilin Z   Stivers David N DN   Meistrich Marvin L ML  

Biology of reproduction 20090814 1


Although gonadotropins and androgen are required for normal spermatogenesis and both testosterone and follicle-stimulating hormone (FSH) are responsible for the inhibition of spermatogonial differentiation that occurs in irradiated rats, it has been difficult to identify the specific genes involved. To study specific hormonally regulated changes in somatic cell gene expression in the testis that may be involved in these processes, without the complication of changing populations of germ cells, w  ...[more]

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