Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Kenneth P Nephew Meng Li
PROVIDER: E-GEOD-15372 | ArrayExpress | 2009-04-17
SECONDARY ACCESSION(S): GSE15372PRJNA123257
REPOSITORIES: GEO, ArrayExpress
BMC medical genomics 20090608
Cisplatin and carboplatin are the primary first-line therapies for the treatment of ovarian cancer. However, resistance to these platinum-based drugs occurs in the large majority of initially responsive tumors, resulting in fully chemoresistant, fatal disease. Although the precise mechanism(s) underlying the development of platinum resistance in late-stage ovarian cancer patients currently remains unknown, CpG-island (CGI) methylation, a phenomenon strongly associated with aberrant gene silencin ...[more]