Transcriptomics

Dataset Information

5

Promoter CpG island methylation data from A2780 (cisplatin-sensitive) and Round5 A2780 (cisplatin-resistant) cell lines.


ABSTRACT: Cisplatin and carboplatin are the primary first-line therapies for the treatment of ovarian cancer. However, resistance to these platinum-based drugs occurs in the large majority of initially responsive tumors, subsequently resulting in a poor long-term prognosis. To model the onset of drug resistance, and investigate the DNA methylation alterations associated with cisplatin resistance, we treated clonally derived, drug-sensitive A2780 epithelial ovarian cancer cells with increasing concentrations of cisplatin. After several cycles of drug selection, the isogenic drug-sensitive and -resistant pairs were subjected to global CGI methylation microarray analyses. We treated clonally derived, drug-sensitive A2780 epithelial ovarian cancer cells with increasing concentrations of cisplatin. After several cycles of drug selection, the isogenic drug-sensitive and -resistant pairs were subjected to global CGI methylation analyses by differential methylation hybridization (DMH) using a customed 44K promoter CGI microarray.

ORGANISM(S): Homo sapiens  

SUBMITTER: Kenneth P Nephew   Meng Li 

PROVIDER: E-GEOD-15373 | ArrayExpress | 2010-06-19

SECONDARY ACCESSION(S): GSE15373PRJNA122939

REPOSITORIES: GEO, ArrayExpress

Similar Datasets

2009-04-17 | GSE15373 | GEO
| GSE15372 | GEO
2009-04-17 | E-GEOD-15372 | ArrayExpress
2013-10-25 | E-GEOD-51683 | ArrayExpress
2012-10-04 | E-MEXP-2840 | ArrayExpress
2009-04-17 | E-GEOD-15709 | ArrayExpress
2016-07-06 | PXD001176 | Pride
2011-12-20 | E-GEOD-28647 | ArrayExpress
2011-12-20 | E-GEOD-28648 | ArrayExpress
2018-10-24 | PXD002825 | Pride