Transcriptomics

Dataset Information

4

Cyclin K and cyclin D1b are oncogenic in myeloma cells


ABSTRACT: To study the oncogenic potential of cyclin D1b in the context of mature B cells we generated several cell clones derived from LP-1 MM cell line expressing either cyclin D1b, Myc or cyclin K oncogenes. Transcriptomic analysis allowed us to describe several mechanisms of cyclin D1b- and K-mediated oncogenesis. Three-condition experiment: LP-1cl1, LP-1K and LP-1D1b. Multiple myeloma LP-1 cell lines. Biological replicates: 4 control (LP-1cl1), 4 transfected with cyclin K (Lp-1K) and 4 transfected with cyclin D1b (LP-1D1b) independently grown and harvested. One replicate per array.

ORGANISM(S): Homo sapiens  

SUBMITTER: Geoffroy Andrieux   Jack-Michel Renoir  Bernard Jost  Veronique Marsaud  Jian-Miao Liu  Guergana Tchakarska  Doulaye Dembele  Brigitte Sola  Joanna Wdzieczak-Bakala 

PROVIDER: E-GEOD-15497 | ArrayExpress | 2010-04-23

SECONDARY ACCESSION(S): GSE15497PRJNA115659

REPOSITORIES: GEO, ArrayExpress

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Publications


BACKGROUND: Aberrant expression of cyclin D1 is a common feature in multiple myeloma (MM) and always associated with mantle cell lymphoma (MCL). CCND1 gene is alternatively spliced to produce two cyclin D1 mRNA isoforms which are translated in two proteins: cyclin D1a and cyclin D1b. Both isoforms are present in MM cell lines and primary cells but their relative role in the tumorigenic process is still elusive. RESULTS: To test the tumorigenic potential of cyclin D1b in vivo, we generated cell c  ...[more]

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