Transcriptomics

Dataset Information

5

Expression data from uterine endometrial tissues of Holstein-Friesian cows on days 14-16 after calving


ABSTRACT: Most dairy cows suffer uterine microbial contamination postpartum. Persistent endometritis often develops, associated with reduced fertility. We used a model of differential feeding and milking regimes to produce cows in differing negative energy balance (NEB) status in early lactation. We used Affymetrix GeneChipÒ Bovine Genome Array to investigate the global gene expression underlying negative energy balance and to identify the significantly differentially expressed genes during this process. We investigate the differences of gene expression profiles in uterine endometrial tissues between the cows with mild and severe negative energy balance.

ORGANISM(S): Bos taurus  

SUBMITTER: Dermot G Morris   Waliul Chowdhury  Zhangrui Cheng  Mark A Fenwick  Joe Patton  John J Murphy  Richard Fitzpatrick  D C Wathes 

PROVIDER: E-GEOD-15544 | ArrayExpress | 2009-04-04

SECONDARY ACCESSION(S): GSE15544PRJNA115979

REPOSITORIES: GEO, ArrayExpress

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Publications

Negative energy balance alters global gene expression and immune responses in the uterus of postpartum dairy cows.

Wathes D Claire DC   Cheng Zhangrui Z   Chowdhury Waliul W   Fenwick Mark A MA   Fitzpatrick Richard R   Morris Dermot G DG   Patton Joe J   Murphy John J JJ  

Physiological genomics 20090630 1


Most dairy cows suffer uterine microbial contamination postpartum. Persistent endometritis often develops, associated with reduced fertility. We used a model of differential feeding and milking regimes to produce cows in differing negative energy balance status in early lactation (mild or severe, MNEB or SNEB). Blood hematology was assessed preslaughter at 2 wk postpartum. RNA expression in endometrial samples was compared using bovine Affymetrix arrays. Data were mapped using Ingenuity Pathway  ...[more]

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