Transcriptomics

Dataset Information

3

Transcription profiling of mouse overexpressing APPSw mice vs. controls


ABSTRACT: Gene expression changes in mice overexpressing amyloid precursor protein with the Swedish mutation (Tg2576; APPSw). The gene expression levels in male 12 month-old APPSw mice (GSM26708, GSM26709) were compared to those in male nontransgenic littermate control mice (GSM26706, GSM26707). Data were analyzed with MAS 5.0 and scaled to 2500. See Stein, TD, Anders, NJ, DeCarli, C, Chan, SL, Mattson, MP, and Johnson JA. Neutralization of transthyretin reverses the neuroprotective effects of secreted APP in APPSw mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. J Neurosci. in press.

ORGANISM(S): Mus musculus  

SUBMITTER: Thor D. Stein  

PROVIDER: E-GEOD-1556 | ArrayExpress | 2008-06-11

SECONDARY ACCESSION(S): GDS811GSE1556PRJNA89961

REPOSITORIES: GEO, ArrayExpress

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