Transcriptomics

Dataset Information

3

Il13-stimulation of human paSMCs


ABSTRACT: Idiopathic pulmonary arterial hypertension (IPAH) is characterized by medial hypertrophy due to pulmonary arterial smooth muscle cell (paSMC) hyperplasia. Interleukin (IL)-13 is a potent regulator of tissue fibrosis and remodelling, and its effects are dependent on the cell-type specific expression of the IL-13 receptor isotypes IL-4Rα, IL-13Rα1, and IL-13Rα2. In order to identify the possible mechanism how IL-13 can exert its antiproliferative effect on paSMC microarray analysis was performed. For this purpose paSMC were stimulated with IL-13(10ng/ml) for 2h and 6h, respectively and subjected to microarray analysis. Comparison of stimulated versus unstimulated cells. 3 biological replicates, 2 time points

ORGANISM(S): Homo sapiens  

SUBMITTER: Norbert Weissmann  Oliver Eickelberg  Rory E Morty  Jürgen Lohmeyer  Walter Klepetko  Ralph T Schermuly  Anna Zakrzewicz  Matthias Hecker  Daniel Sedding  Grażyna Kwapiszewska  Jochen Wilhelm  Zbigniew Zasłona  Werner Seeger  Leigh M Marsh 

PROVIDER: E-GEOD-15739 | ArrayExpress | 2010-05-07

SECONDARY ACCESSION(S): GSE15739PRJNA116629

REPOSITORIES: GEO, ArrayExpress

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