Dataset Information


Gene expression in GLN versus PDLN in NOD mice

ABSTRACT: Comparison of the gene expression in the two pancreatic lymph nodes: gastric lymph node (GLN) and pancreatico-duodenal lymph node (PDLN) in NOD mice. The analysis was done in an attempt to explain the preferential homing of bone marrow-derived dendritic cells to the GLN after intravenous injection. GLN and PDLN were excised from 4 individual 12-wk old female NOD mice and RNA was extracted after tissue homogenization in Trizol for processing onto microarray (Agilent 4x44K). Each array corresponds to one single mouse, thus this study comprise 4 biological replicates.

ORGANISM(S): Mus musculus  

SUBMITTER: Garry Fathman   Remi J Creusot 

PROVIDER: E-GEOD-15753 | ArrayExpress | 2010-04-08



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Lymphoid-tissue-specific homing of bone-marrow-derived dendritic cells.

Creusot Rémi J RJ   Yaghoubi Shahriar S SS   Chang Pearl P   Chia Justine J   Contag Christopher H CH   Gambhir Sanjiv S SS   Fathman C Garrison CG  

Blood 20090410 26

Because of their potent immunoregulatory capacity, dendritic cells (DCs) have been exploited as therapeutic tools to boost immune responses against tumors or pathogens, or dampen autoimmune or allergic responses. Murine bone marrow-derived DCs (BM-DCs) are the closest known equivalent of the blood monocyte-derived DCs that have been used for human therapy. Current imaging methods have proven unable to properly address the migration of injected DCs to small and deep tissues in mice and humans. Th  ...[more]

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