Transcriptomics

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Identification of potential therapeutic targets for Burkholderia cenocepacia by comparative transcriptomics


ABSTRACT: [1] Transcription profiling of one Burkholderia cenocepacia clinical isolate, J2315, versus a soil isolate, HI2424, in conditions mimicking CF sputum [2] Transcription profiling of Burkholderia cenocepacia isolates J2315 and HI2424 in media mimicking CF sputum or the soil environment [1] J2315 vs. HI2424 cells in the same condition. [2] Two-condition experiment. Biological replicates: 4 replicates.

ORGANISM(S): Burkholderia cenocepacia  

SUBMITTER: James M Tiedje  Deborah R Yoder-Himes  Kostantinos T Konstantinidis  Deborah R. Yoder-Himes 

PROVIDER: E-GEOD-15817 | ArrayExpress | 2010-05-19

SECONDARY ACCESSION(S): GSE15817PRJNA116735

REPOSITORIES: GEO, ArrayExpress

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Publications

Identification of potential therapeutic targets for Burkholderia cenocepacia by comparative transcriptomics.

Yoder-Himes Deborah R DR   Konstantinidis Konstantinos T KT   Tiedje James M JM  

PloS one 20100115 1


Burkholderia cenocepacia is an endemic soil dweller and emerging opportunistic pathogen in patients with cystic fibrosis (CF). The identification of virulence factors and potential therapeutic targets has been hampered by the genomic diversity within the species as many factors are not shared among the pathogenic members of the species.In this study, global identification of putative virulence factors was performed by analyzing the transcriptome of two related strains of B. cenocepacia (one clin  ...[more]

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