Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Melissa Troester
PROVIDER: E-GEOD-15948 | ArrayExpress | 2010-05-08
SECONDARY ACCESSION(S): GSE15948PRJNA117005
REPOSITORIES: GEO, ArrayExpress
Gauger Kelly J KJ Hugh Jeremy M JM Troester Melissa A MA Schneider Sallie Smith SS
Cancer Cell International 20090507
BACKGROUND: The Wnt family of secreted proteins is implicated in the regulation of cell fate during development, as well as in cell proliferation, morphology, and migration. Aberrant activation of the Wnt/beta-catenin signaling pathway leads to the development of several human cancers, including breast cancer. Secreted frizzled-related protein 1 (SFRP1) antagonizes this pathway by competing with the Frizzled receptor for Wnt ligands resulting in an attenuation of the signal transduction cascade. ...[more]