Dataset Information


Bdellovibrio bacteriovorus attack phase and Host-Independent grown cells

ABSTRACT: Bdellovibrio is a Gram-negative bacterium that preys upon other Gram-negative bacteria, including many pathogens, and as such has potential as a biocontrol agent. Little is known of the molecular and genetic control of Bdellovibrio’s attack upon its prey and of the nature of the HI phenotype. Here, we apply microarray technology to monitor changes of gene expression during the initial stages of prey infection to determine which predatory genes are important in this stage and to gain insight into possible regulatory mechanisms controlling the predation process. Comparison to gene expression during HI growth reveals a “predatosome” of genes specifically upregulated during predation and implicates some of those important in HI growth. 3 replicates of attack phase cells and 3 replicates of Host-Independent grown cells were analysed on individual arrays.

ORGANISM(S): Bdellovibrio bacteriovorus  

SUBMITTER: Carey Lambert   Liz Sockett 

PROVIDER: E-GEOD-16034 | ArrayExpress | 2010-05-18



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The first bite--profiling the predatosome in the bacterial pathogen Bdellovibrio.

Lambert Carey C   Chang Chien-Yi CY   Capeness Michael J MJ   Sockett R Elizabeth RE  

PloS one 20100106 1

Bdellovibrio bacteriovorus is a Gram-negative bacterium that is a pathogen of other Gram-negative bacteria, including many bacteria which are pathogens of humans, animals and plants. As such Bdellovibrio has potential as a biocontrol agent, or living antibiotic. B. bacteriovorus HD100 has a large genome and it is not yet known which of it encodes the molecular machinery and genetic control of predatory processes. We have tried to fill this knowledge-gap using mixtures of predator and prey mRNAs  ...[more]

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