Transcriptomics,Multiomics

Dataset Information

4

Effect of Ovarian Hormone on Gene Expression in Laser Captured Serotonin Neurons from Monkeys


ABSTRACT: Ovariectomized monkeys were treated with placebo, estrogen or estrogen plus progesterone for one month. The brain was perfused with RNA Later plus 20% sucrose. Sections through the dorsal raphe nucleus were immunostained for TPH and then TPH positive neurons were laser captured. The RNA was extracted and hybridized to the Rhesus Affymetrix chip. Each chip represents one monkey. N=2 monkeys per treatment.

OTHER RELATED OMICS DATASETS IN: PRJNA117191

ORGANISM(S): Macaca mulatta  

SUBMITTER: Arubala P. Reddy   Arubala P Reddy  Cynthia L Bethea 

PROVIDER: E-GEOD-16169 | ArrayExpress | 2010-04-08

SECONDARY ACCESSION(S): GSE16169PRJNA117191

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-16169.README.txt Txt
E-GEOD-16169.eSet.r Other
E-GEOD-16169.idf.txt Idf
E-GEOD-16169.processed.1.zip Processed
E-GEOD-16169.raw.1.zip Raw
Items per page:
1 - 5 of 6
altmetric image

Publications

Effect of ovarian hormones on survival genes in laser captured serotonin neurons from macaques.

Bethea Cynthia L CL   Reddy Arubala P AP  

Journal of neurochemistry 20080107 4


We sought the effect of estradiol (E) and progesterone (P) on survival gene expression in laser captured serotonin neurons and in the dorsal raphe region of monkeys with cDNA array analysis. Spayed rhesus macaques were treated with either placebo, E or E + P via Silastic implant for 1 month prior to killing. First, RNA from a small block of midbrain containing the dorsal raphe was hybridized to Rhesus Gene Chips (n = 3/treatment). There was a significant change in 854 probe sets with E +/- P tre  ...[more]

Similar Datasets

2009-05-21 | GSE16169 | GEO
2009-05-21 | E-GEOD-16171 | ArrayExpress
2010-04-09 | E-GEOD-16172 | ArrayExpress
2009-05-21 | GSE16171 | GEO
2009-05-21 | GSE16172 | GEO
2006-01-01 | S-EPMC1413962 | BioStudies
2010-01-01 | S-EPMC3910421 | BioStudies
2009-01-01 | S-EPMC2762017 | BioStudies
2013-01-01 | S-EPMC3654014 | BioStudies
2014-01-01 | S-EPMC4181537 | BioStudies