Transcriptomics,Multiomics

Dataset Information

4

Effect of Ovarian Hormone on Gene Expression in Rhesus Dorsal Raphe Nucleus with Human U95A Affymetrix Chip


ABSTRACT: Small blocks of the midbrain containing the dorsal raphe nucleus was obtained from ovariectomized monkeys treated with placebo, estrogen, progesterone or estrogen plus progesterone for one month. The RNA was extracted and hybridized to the human U95A Affymetrix chip. Each chip represents one monkey. N=3 monkeys per treatment.

OTHER RELATED OMICS DATASETS IN: PRJNA115055

ORGANISM(S): Macaca mulatta  

SUBMITTER: Arubala P. Reddy   Arubala P Reddy  Cynthia L Bethea 

PROVIDER: E-GEOD-16171 | ArrayExpress | 2009-05-21

SECONDARY ACCESSION(S): GSE16171PRJNA115055

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-16171.README.txt Txt
E-GEOD-16171.eSet.r Other
E-GEOD-16171.idf.txt Idf
E-GEOD-16171.processed.1.zip Processed
E-GEOD-16171.raw.1.zip Raw
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Publications

Preliminary array analysis reveals novel genes regulated by ovarian steroids in the monkey raphe region.

Reddy Arubala P AP   Bethea Cynthia L CL  

Psychopharmacology 20050225 1


We hypothesize that ovarian hormones may improve serotonin neuron survival. We sought the effect of estradiol (E) and progesterone (P) on novel gene expression in the macaque dorsal raphe region with Affymetrix array analysis. Nine spayed rhesus macaques were treated with either placebo, E or E+P via Silastic implant for 1 month prior to euthanasia (n=3 per treatment). RNA was extracted from a small block of midbrain containing the dorsal raphe and examined on an Agilent Bioanalyzer. The RNA fro  ...[more]

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