Ontology highlight
ABSTRACT:
REANALYSED by: E-GEOD-16193
ORGANISM(S): Homo sapiens
SUBMITTER: Peter J Munson Jennifer Barb Robert L Danner Gabriela A Ferreyra Maneesha Chhikara
PROVIDER: E-GEOD-16193 | ArrayExpress | 2010-06-08
SECONDARY ACCESSION(S): GSE16193PRJNA117203
REPOSITORIES: GEO, ArrayExpress
PloS one 20091202 12
Carbon monoxide (CO) is an endogenous messenger that suppresses inflammation, modulates apoptosis and promotes vascular remodeling. Here, microarrays were employed to globally characterize the CO (250 ppm) suppression of early (1 h) LPS-induced inflammation in human monocytic THP-1 cells. CO suppressed 79 of 101 immediate-early genes induced by LPS; 19% (15/79) were transcription factors and most others were cytokines, chemokines and immune response genes. The prototypic effects of CO on transcr ...[more]