Dataset Information


Transcription profiling of mouse joint tissue from C3H and interval specific congenic mouse lines post- B. burgdorferi infection

ABSTRACT: Gene expression profile of joint tissue from C3H and interval specific congenic mouse lines (ISCL) following infection with Borrelia burgdorferi; Congenic lines of mice generated between C3H and C57BL/6 with penetrant arthritis severity phenotype were infected with B. burgdorferi; Joint tissue was collected from uninfected control mice and from mice infected for 1 week, RNA was prepared and gene expressed analyzed by Affymetrix microarray. Experiment Overall Design: Each sample was comprised of pooled RNA from at least 5 female mice of each genotype.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Mus musculus  

SUBMITTER: Janis Weis  

PROVIDER: E-GEOD-16195 | ArrayExpress | 2009-07-01



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Interval-specific congenic lines reveal quantitative trait Loci with penetrant lyme arthritis phenotypes on chromosomes 5, 11, and 12.

Ma Ying Y   Miller Jennifer C JC   Crandall Hillary H   Larsen Eric T ET   Dunn Diane M DM   Weiss Robert B RB   Subramanian Meenakumari M   Weis John H JH   Zachary James F JF   Teuscher Cory C   Weis Janis J JJ  

Infection and immunity 20090601 8

The observation that Borrelia burgdorferi-induced arthritis is severe in C3H mice and milder in C57BL/6 (B6) mice has allowed a forward genetics approach for the identification of genetic elements that regulate the arthritis response. Quantitative trait loci (QTL) on five chromosomes (Chr) were identified previously in segregating crosses between C3H and B6 mice and collectively designated B. burgdorferi arthritis-associated (Bbaa) QTL. Reciprocal interval-specific congenic lines (ISCL) that enc  ...[more]

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