Transcriptomics

Dataset Information

7

RNAi knock down of MAFin human lymphatic endothelial cells


ABSTRACT: Kaposi sarcoma is the most common cancer in AIDS patients and is typified by red skin lesions. The disease is caused by the KSHV virus (HHV8) and is recognisable by its distinctive red skin lesions. The lesions are KSHV-infected spindle cells, most commonly the lymphatic endothelial and blood vessel endothelial cells (LEC and BEC), plus surrounding stroma. The KSHV virus expresses multiple MAF-downregulating microRNA. Here we test the effects of MAF silencing by siRNA in LEC cells using Affymetrix hgu133plus2 chips. Experiment Overall Design: There are n=3 of 1. LEC control cells transfected with a non-targeting siRNA, 2. LEC transfected with a MAF-targeting siRNA

ORGANISM(S): Homo sapiens  

SUBMITTER: Stephen Henderson  

PROVIDER: E-GEOD-16356 | ArrayExpress | 2009-10-10

SECONDARY ACCESSION(S): GSE16356PRJNA122847

REPOSITORIES: GEO, ArrayExpress

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