Dataset Information


Gene expression profiling of muscles from transgenic humanSODG93A mice at presymptomatic stage

ABSTRACT: The transgenic mice expressing the human mutated form (G93A) of the SOD1 gene represent a valuable model of Amyotrophic Lateral Sclerosis (ALS). SOD1 is one of the main causative genes of familial ALS which accounts for 10% of cases. These transgenic animals develop a motorneuronal pathology that recapitulates well the neuropathological features occuring in ALS patients, and the progression of the disease can be monitored by a series of motor tests. Gastrocnemius is the first and most affected muscle in the disease, while triceps is relatively spared. Gene expression data of degenerating motor neurons at different disease stages are already available, while gene expression data on the muscle tissue are missing. Our aim is to define the role of muscle in motor neuron degeneration in ALS. Keywords: Single stage analysis (presymptomatic stage, 7 week-old mice) We considered two sets of muscle at presymptomatic stage (7 weeks): gastrocnemius and triceps from 4 transgenic SOD1G93A and 4 non-transgenic mice (NTg).


ORGANISM(S): Mus musculus  

SUBMITTER: Stefano Calza   Antonia Ratti  Manuela Volta 

PROVIDER: E-GEOD-16360 | ArrayExpress | 2010-03-04



Similar Datasets

2009-06-02 | GSE16360 | GEO
2009-06-02 | GSE16361 | GEO
2015-09-03 | E-GEOD-16360 | ExpressionAtlas
2010-03-04 | E-GEOD-16361 | ArrayExpress
2015-09-03 | E-GEOD-16361 | ExpressionAtlas
2012-12-04 | E-GEOD-38820 | ArrayExpress
2010-06-24 | GSE22482 | GEO
2010-07-30 | E-GEOD-22482 | ArrayExpress
2007-04-11 | GSE7493 | GEO
2008-01-05 | E-TABM-195 | ArrayExpress