Transcriptomics

Dataset Information

12

MiRNA expression profiling in high-risk neuroblastoma


ABSTRACT: In the present study we evaluated the miRNA expression profile of 31 high risk, stage 4 neuroblastoma patients. We compared miRNA expression profiles of 14 long-survivors (alive with an overall survival time > 36 months) and 17 short-survivors (dead of disease within 36 months from diagnosis. Deaths due to toxicity were censored).

ORGANISM(S): Homo sapiens  

SUBMITTER: Sara Stigliani   Paola Scaruffi  PAOLA SCARUFFI  Simona Coco 

PROVIDER: E-GEOD-16444 | ArrayExpress | 2010-05-16

SECONDARY ACCESSION(S): GSE16444PRJNA116347

REPOSITORIES: GEO, ArrayExpress

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Publications

Transcribed-Ultra Conserved Region expression is associated with outcome in high-risk neuroblastoma.

Scaruffi Paola P   Stigliani Sara S   Moretti Stefano S   Coco Simona S   De Vecchi Carla C   Valdora Francesca F   Garaventa Alberto A   Bonassi Stefano S   Tonini Gian Paolo GP  

BMC cancer 20091215


BACKGROUND: Neuroblastoma is the most common, pediatric, extra-cranial, malignant solid tumor. Despite multimodal therapeutic protocols, outcome for children with a high-risk clinical phenotype remains poor, with long-term survival still less than 40%. Hereby, we evaluated the potential of non-coding RNA expression to predict outcome in high-risk, stage 4 neuroblastoma. METHODS: We analyzed expression of 481 Ultra Conserved Regions (UCRs) by reverse transcription-quantitative real-time PCR and o  ...[more]

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