Transcriptomics

Dataset Information

241

Age-associated alteration of gene expression patterns in mouse oocytes


ABSTRACT: Decreasing oocyte competence with maternal aging is a major factor in human infertility. To investigate the age-dependent molecular changes in a mouse model, we compared the expression profiles of metaphase II oocytes collected from 5-6 week old mice with those collected from 40-42 week old mice using the NIA 22K 60-mer oligo microarray.

ORGANISM(S): Mus musculus  

SUBMITTER: Hidenori Akutsu   Minoru S.H. Ko  Mark G Carter  Vincent VanBuren  Dawood B Dudekula  Minoru S Ko  Alexei A Sharov  Carole A Stagg  Toshio Hamatani  Geppino Falco 

PROVIDER: E-GEOD-1646 | ArrayExpress | 2010-06-06

SECONDARY ACCESSION(S): GSE1646PRJNA90699

REPOSITORIES: GEO, ArrayExpress

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Publications

Age-associated alteration of gene expression patterns in mouse oocytes.

Hamatani Toshio T   Falco Geppino G   Carter Mark G MG   Akutsu Hidenori H   Stagg Carole A CA   Sharov Alexei A AA   Dudekula Dawood B DB   VanBuren Vincent V   Ko Minoru S H MS  

Human molecular genetics 20040818 19


Decreasing oocyte competence with maternal aging is a major factor in human infertility. To investigate the age-dependent molecular changes in a mouse model, we compared the expression profiles of metaphase II oocytes collected from 5- to 6-week-old mice with those collected from 42- to 45-week-old mice using the NIA 22K 60-mer oligo microarray. Among approximately 11,000 genes whose transcripts were detected in oocytes, about 5% (530) showed statistically significant expression changes, excludi  ...[more]

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