Transcriptomics

Dataset Information

48

C. elegans : Control vs. Chlorpyrifos (0.5mg/ml) treatment


ABSTRACT: Transcriptional profile of C. elegans comparing control vs. nematodes treated with 0.5mg/ml of Chorpyrifos (CPF) at 16°C. Toxicant was added to agar and nematode culture on petri dishes for 72h before harvesting. One condition experiment with six biological replicates in a dye swap design.

ORGANISM(S): Caenorhabditis elegans  

SUBMITTER: Ana Viñuela  Jan E Kammenga   Ana Viñuela    

PROVIDER: E-GEOD-16688 | ArrayExpress | 2014-05-02

SECONDARY ACCESSION(S): GSE16688PRJNA122699

REPOSITORIES: GEO, ArrayExpress

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Publications

Genome-wide gene expression analysis in response to organophosphorus pesticide chlorpyrifos and diazinon in C. elegans.

Viñuela Ana A   Snoek L Basten LB   Riksen Joost A G JA   Kammenga Jan E JE  

PloS one 20100816 8


Organophosphorus pesticides (OPs) were originally designed to affect the nervous system by inhibiting the enzyme acetylcholinesterase, an important regulator of the neurotransmitter acetylcholine. Over the past years evidence is mounting that these compounds affect many other processes. Little is known, however, about gene expression responses against OPs in the nematode Caenorhabditis elegans. This is surprising because C. elegans is extensively used as a model species in toxicity studies. To a  ...[more]

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