Transcriptomics,Multiomics

Dataset Information

42

Transcription profiling by array of Rattus norvegicus proximal tibial growth plates at different ages


ABSTRACT: To explore the mechanisms responsible for spatial and temporal regulation of the growth plate, we microdissected postnatal rat growth plates into their constituent zones and then used microarray analysis to characterize the changes in gene expression that occur as chondrocytes undergo spatially-associated differentiation and temporally-associated senescence. Microdissection was used to collect individual growth plate zones from proximal tibiae of 1-wk rats and the proliferative and early hypertrophic zones of growth plates from 3-, 6-, 9-, and 12-wk rats and gene expression was analyzed using microarray.

REANALYSED by: E-GEOD-16981

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Anenisia C Andrade  Anita Hegde   Jeffrey Baron   Ola Nilsson   Wei P Chen   Julian C Lui    

PROVIDER: E-GEOD-16981 | ArrayExpress| 2015-09-04

SECONDARY ACCESSION(S): GSE16981PRJNA117283

REPOSITORIES: GEO, ArrayExpress

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Publications

Spatial and temporal regulation of gene expression in the mammalian growth plate.

Lui Julian C K JC   Andrade Anenisia C AC   Forcinito Patricia P   Hegde Anita A   Chen WeiPing W   Baron Jeffrey J   Nilsson Ola O  

Bone 20100122 5


Growth plates are spatially polarized and structured into three histologically and functionally distinct layers-the resting zone (RZ), proliferative zone (PZ), and hypertrophic zone (HZ). With age, growth plates undergo functional and structural senescent changes including declines of growth rate, proliferation rate, growth plate height and cell number. To explore the mechanisms responsible for spatially-associated differentiation and temporally-associated senescence of growth plate in an unbias  ...[more]

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