Dataset Information


Transcription profiling by array of Rattus norvegicus proximal tibial growth plates at different ages

ABSTRACT: To explore the mechanisms responsible for spatial and temporal regulation of the growth plate, we microdissected postnatal rat growth plates into their constituent zones and then used microarray analysis to characterize the changes in gene expression that occur as chondrocytes undergo spatially-associated differentiation and temporally-associated senescence. Microdissection was used to collect individual growth plate zones from proximal tibiae of 1-wk rats and the proliferative and early hypertrophic zones of growth plates from 3-, 6-, 9-, and 12-wk rats and gene expression was analyzed using microarray.


ORGANISM(S): Rattus norvegicus  

SUBMITTER: Anenisia C Andrade   Anita Hegde  Jeffrey Baron  Ola Nilsson  Wei P Chen  Julian C Lui 

PROVIDER: E-GEOD-16981 | ArrayExpress | 2010-02-22



altmetric image


Spatial and temporal regulation of gene expression in the mammalian growth plate.

Lui Julian C K JC   Andrade Anenisia C AC   Forcinito Patricia P   Hegde Anita A   Chen WeiPing W   Baron Jeffrey J   Nilsson Ola O  

Bone 20100122 5

Growth plates are spatially polarized and structured into three histologically and functionally distinct layers-the resting zone (RZ), proliferative zone (PZ), and hypertrophic zone (HZ). With age, growth plates undergo functional and structural senescent changes including declines of growth rate, proliferation rate, growth plate height and cell number. To explore the mechanisms responsible for spatially-associated differentiation and temporally-associated senescence of growth plate in an unbias  ...[more]

Similar Datasets

2015-09-04 | E-GEOD-16981 | ExpressionAtlas
2010-12-01 | E-GEOD-23432 | ArrayExpress
2010-01-28 | GSE16981 | GEO
2014-08-16 | E-GEOD-54216 | ArrayExpress
2010-12-01 | GSE23432 | GEO
2010-05-01 | E-GEOD-18338 | ArrayExpress
2013-09-13 | E-GEOD-9160 | ArrayExpress
| GSE9160 | GEO
2015-08-21 | E-GEOD-72261 | ArrayExpress
2008-03-28 | GSE9537 | GEO