Transcriptomics

Dataset Information

4

Expression profiling of sox11-expressing glioma-initiating cell-like cells


ABSTRACT: To identify factors involved in tumorigenicity of glioma-initiating cells (GICs), we compared gene expression in GIC-like cells with and without sox11 expression. We established sox11-expressing mouse glioma-initiating cell (GIC)-like cell line (NSCL61s), NSCL61s-sox11, which lost tumorigenicity when transplanted in vivo. We think that genes, which are differently expressed between NSCL61s and NSCL61s-sox11, would be new targets for glioma therapy.

ORGANISM(S): Mus musculus  

SUBMITTER: Toru Kondo  

PROVIDER: E-GEOD-17076 | ArrayExpress | 2009-11-30

SECONDARY ACCESSION(S): GSE17076PRJNA123401

REPOSITORIES: GEO, ArrayExpress

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Publications

Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation.

Hide Takuichiro T   Takezaki Tatsuya T   Nakatani Yuka Y   Nakamura Hideo H   Kuratsu Jun-ichi J   Kondo Toru T  

Cancer research 20091006 20


Recent findings have shown that malignant tumors contain cancer-initiating cells (CIC), which self-renew and are tumorigenic. However, CICs have not been characterized properly due to lack of specific markers. We recently established a mouse glioma cell line, NSCL61, by overexpressing an oncogenic HRas(L61) in p53-deficient neural stem cells. Using limiting dilution assays, we show that only 2 of 24 NSCL61 clones retained their tumorigenicity in vivo, although the others also expressed oncogenic  ...[more]

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