Dataset Information


Effects of pulp and paper mill effluents on gene expression in the fathead minnow hypothalamus

ABSTRACT: We evaluated the possible mechanisms by which exposures to pulp and paper mill effluents gene expression in the fathead minnow hypothalamus Keywords: Toxicology Sexually mature fathead minnows were exposed to 100% pulp and paper mill effluents for 5 days. Tanks contained 4 females and 2 males. A total 4 tanks per effluents were used in this experiment. TM5, TM6, and KM4 represent different pulp and paper mill effluents from different mills coded for by FPInnovations-Paprican.

ORGANISM(S): Pimephales promelas  

SUBMITTER: Jason T. Popesku   Jason T Popesku  Andrew Williams  Carole L Yauk  Andrea Rowan-Carroll  Vance L Trudeau 

PROVIDER: E-GEOD-17130 | ArrayExpress | 2010-07-07



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Gene expression profiling of the fathead minnow (Pimephales promelas) neuroendocrine brain in response to pulp and paper mill effluents.

Popesku Jason T JT   Tan Elvin Y Z EY   Martel Pierre H PH   Kovacs Tibor G TG   Rowan-Carroll Andrea A   Williams Andrew A   Yauk Carole C   Yauk Carole C   Trudeau Vance L VL  

Aquatic toxicology (Amsterdam, Netherlands) 20100604 3

The toxicity of pulp and paper mill effluents (PPMEs) has been greatly decreased, yet some continue to negatively affect fish reproduction. We hypothesized that PPMEs are affecting the brain resulting in decreased reproductive performance. Our goal was to use gene expression profiling to test the hypothesis that PPMEs are having an effect on neural systems in the fathead minnow (FHM; Pimephales promelas) in vivo. Sexually mature male and female FHM were exposed to 100% final biotreated PPMEs fro  ...[more]

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