Dataset Information

Effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells

ABSTRACT: Monoamine oxidase A (MAO-A), a mitochondrial enzyme that degrades monoamines including neurotransmitters, is highly expressed in basal cells of the normal human prostatic epithelium and in poorly differentiated (Gleason grades 4 and 5), aggressive prostate cancer (PCa). Clorgyline, an MAO-A inhibitor, induces secretory differentiation of normal prostate cells. We systematically assessed gene expression changes induced by clorgyline in E-CA cells using high-density oligonucleotide microarrays. Genes differentially expressed in treated and control cells were identified by Significance Analysis of Microarrays. Expression of genes of interest was validated by quantitative real-time polymerase chain reaction. time series design

ORGANISM(S): Homo sapiens

SUBMITTER: Hongjuan Zhao Donna M Peehl

PROVIDER: E-GEOD-17167 | ArrayExpress | 2010-07-17

SECONDARY ACCESSION(S): GSE17167PRJNA119769

REPOSITORIES: GEO, ArrayExpress

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Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells.

Zhao Hongjuan H Flamand Vincent V Peehl Donna M DM

BMC medical genomics 20090820

Monoamine oxidase A (MAO-A), a mitochondrial enzyme that degrades monoamines including neurotransmitters, is highly expressed in basal cells of the normal human prostatic epithelium and in poorly differentiated (Gleason grades 4 and 5), aggressive prostate cancer (PCa). Clorgyline, an MAO-A inhibitor, induces secretory differentiation of normal prostate cells. We examined the effects of clorgyline on the transcriptional program of epithelial cells cultured from high grade PCa (E-CA).We systemati ...[more]

PMID: 19691856

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