Transcriptomics

Dataset Information

4

Effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells


ABSTRACT: Monoamine oxidase A (MAO-A), a mitochondrial enzyme that degrades monoamines including neurotransmitters, is highly expressed in basal cells of the normal human prostatic epithelium and in poorly differentiated (Gleason grades 4 and 5), aggressive prostate cancer (PCa). Clorgyline, an MAO-A inhibitor, induces secretory differentiation of normal prostate cells. We systematically assessed gene expression changes induced by clorgyline in E-CA cells using high-density oligonucleotide microarrays. Genes differentially expressed in treated and control cells were identified by Significance Analysis of Microarrays. Expression of genes of interest was validated by quantitative real-time polymerase chain reaction. time series design

ORGANISM(S): Homo sapiens  

SUBMITTER: Hongjuan Zhao   Donna M Peehl 

PROVIDER: E-GEOD-17167 | ArrayExpress | 2010-07-17

SECONDARY ACCESSION(S): GSE17167PRJNA119769

REPOSITORIES: GEO, ArrayExpress

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Publications

Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells.

Zhao Hongjuan H   Flamand Vincent V   Peehl Donna M DM  

BMC medical genomics 20090820


Monoamine oxidase A (MAO-A), a mitochondrial enzyme that degrades monoamines including neurotransmitters, is highly expressed in basal cells of the normal human prostatic epithelium and in poorly differentiated (Gleason grades 4 and 5), aggressive prostate cancer (PCa). Clorgyline, an MAO-A inhibitor, induces secretory differentiation of normal prostate cells. We examined the effects of clorgyline on the transcriptional program of epithelial cells cultured from high grade PCa (E-CA).We systemati  ...[more]

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