Effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: 
Hongjuan Zhao Donna M Peehl
PROVIDER: E-GEOD-17167 | ArrayExpress | 2010-07-17
SECONDARY ACCESSION(S): GSE17167PRJNA119769
REPOSITORIES: GEO, ArrayExpress
Publications
Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells.
Zhao Hongjuan H Flamand Vincent V Peehl Donna M DM
BMC medical genomics 20090820
<h4>Background</h4>Monoamine oxidase A (MAO-A), a mitochondrial enzyme that degrades monoamines including neurotransmitters, is highly expressed in basal cells of the normal human prostatic epithelium and in poorly differentiated (Gleason grades 4 and 5), aggressive prostate cancer (PCa). Clorgyline, an MAO-A inhibitor, induces secretory differentiation of normal prostate cells. We examined the effects of clorgyline on the transcriptional program of epithelial cells cultured from high grade PCa ...[more]
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