Dataset Information


Expression data comparing human foreskin keratinocytes to epithelial derivatives of human embryonic stem cells (H9)

ABSTRACT: Whole genome expression array comparison of primary keratinocytes to retinoic acid-differentiated hES cell derivatives Cells were differentiated according to Metallo et al. Stem Cells 2008 A 3 chip study was conducted using competitive hybridization comparing pFKs to hEKs obtained in 3 independent differentiation experiments

ORGANISM(S): Homo sapiens  

SUBMITTER: Sean P Palecek   Christian Metallo  Christian M Metallo 

PROVIDER: E-GEOD-17265 | ArrayExpress | 2010-05-06



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Human embryonic stem cell-derived keratinocytes exhibit an epidermal transcription program and undergo epithelial morphogenesis in engineered tissue constructs.

Metallo Christian M CM   Azarin Samira M SM   Moses Laurel E LE   Ji Lin L   de Pablo Juan J JJ   Palecek Sean P SP  

Tissue engineering. Part A 20100101 1

Human embryonic stem (hES) cells are an attractive source of cellular material for scientific, diagnostic, and potential therapeutic applications. Protocols are now available to direct hES cell differentiation to specific lineages at high purity under relatively defined conditions; however, researchers must establish the functional similarity of hES cell derivatives and associated primary cell types to validate their utility. Using retinoic acid to initiate differentiation, we generated high-pur  ...[more]

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