Transcriptomics

Dataset Information

0

Kc167 ORC2 Localization


ABSTRACT: modENCODE_submission_674 This submission comes from a modENCODE project of David MacAlpine. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We will precisely identify sequence elements that direct DNA replication by using chromatin immunoprecipitation of known replication initiation complexes. These experiments will be conducted in multiple cell types and developmental tissues. Keywords: CHIP-chip For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODEDataReleasePolicyFinal2008.pdf EXPERIMENT TYPE: CHIP-chip. BIOLOGICAL SOURCE: Cell Line: Kc167; Tissue: embryo-derived cell-line; Genotype: se/e; Sex: Female NUMBER OF REPLICATES: 2; EXPERIMENTAL FACTORS: Antibody dORC2

ORGANISM(S): Drosophila melanogaster  

SUBMITTER: Heather MacAlpine  David MacAlpine   DCC modENCODE    

PROVIDER: E-GEOD-17282 | ArrayExpress | 2010-05-15

SECONDARY ACCESSION(S): GSE17282

REPOSITORIES: GEO, ArrayExpress

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Publications

Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading.

MacAlpine Heather K HK   Gordân Raluca R   Powell Sara K SK   Hartemink Alexander J AJ   MacAlpine David M DM  

Genome research 20091207 2


The origin recognition complex (ORC) is an essential DNA replication initiation factor conserved in all eukaryotes. In Saccharomyces cerevisiae, ORC binds to specific DNA elements; however, in higher eukaryotes, ORC exhibits little sequence specificity in vitro or in vivo. We investigated the genome-wide distribution of ORC in Drosophila and found that ORC localizes to specific chromosomal locations in the absence of any discernible simple motif. Although no clear sequence motif emerged, we were  ...[more]

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