Transcriptomics

Dataset Information

3

The effect of IFNα on human CD8 T cells_with other concomitant signals


ABSTRACT: IFN alpha mediated gene expression pattern. The effect of IFN alpha on human CD8 T cells responding to antigen (signal 1) and costimulatory signals (signal 2) provided by beads coated with anti-CD3 and anti-CD28 mAbs. This analysis examined the effects of IFN alpha on human CD8 T cells responding to antigen (signal 1) and costimulatory signals (signal 2) provided by beads coated with anti-CD3 and anti-CD28 mAbs. Magnetically sorted untouched CD8+CD45R0- T cells from three different donors were unstimulated or stimulated with IFNa2b or with anti-CD3/CD28 Beads alone or along with IFNa2b or IFNa5 for 48 hours. Individual mRNA samples were analyzed using HG-U133A 2.0 array gene chips. Keywords: Gene expression analysis after different stimulation Magnetically sorted untouched CD8+CD45R0-T cells from three different donors (named A, B and C) unstimulated or stimulated with IFN alpha 2b or with anti-CD3/CD28 beads alone or along with IFN alpha 2b or IFN alpha 5 for 48 hours.

ORGANISM(S): Homo sapiens  

SUBMITTER: Jesus Prieto   Fernando Corrales  Izaskun Gabari  Iranzu González  Juan Dubrot  Sandra Hervás-Stubbs  Ignacio Melero  Iranzu Gonzalez  Uxua Mancheño  Pedro Esquiroz  Agnes Le Bon  Juan Ruiz  Jose I Riezu  Asis Palazón  Esther Larrea  Arantza Azpilicueta 

PROVIDER: E-GEOD-17301 | ArrayExpress | 2010-07-23

SECONDARY ACCESSION(S): GSE17301PRJNA123599

REPOSITORIES: GEO, ArrayExpress

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