Dataset Information


Sodium arsenate response of wild type and slt2 deficient cells

ABSTRACT: Wild type (BY4741) Saccharomyces cerevisiae strains and their isogenic slt2 deficient counterparts, were treated for 2 hours with sodium arsenate 100 micromolar. Control (untreated) cells were also collected. Total RNA was extracted and analyzed by microarray hybridization. The data obtained from these experiments allows to determine those genes that are regulated by Slt2 activity after arsenate treatment. The experiments was designed as follows: Four types of samples were used: untreated wild type cells, treated wild type cells, untreated slt2- cells and treated slt2- cells. 3 independent replicates were performed for each experiment.

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: Ana M Matia   Miguel Angel Rodriguez-Gabriel  Miguel A Rodriguez-Gabriel 

PROVIDER: E-GEOD-17364 | ArrayExpress | 2010-07-25



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Slt2 MAPK pathway is essential for cell integrity in the presence of arsenate.

Matia-González Ana M AM   Rodríguez-Gabriel Miguel A MA  

Yeast (Chichester, England) 20100824 1

Arsenate is a common toxic metalloid found in drinking water worldwide that causes several human diseases. The biochemical action underlying cellular response to arsenate, however, is not yet completely understood. Here we used Saccharomyces cerevisiae as an eukaryotic model system to identify proteins essential for adaptation to arsenate treatment. Previous studies have demonstrated a function for Hog1 MAPK in modulating the cellular response to arsenite. Our results, however, showed that cells  ...[more]

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