Transcriptomics,Multiomics

Dataset Information

3

Analysis of mRNA expression differences in the skin of Casp-8F/–K5-Cre and Casp-8F/+K5-Cre mice


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE17344: Analysis of spatial mRNA expression differences in the skin of Casp-8F/–K5-Cre or Casp-8F/+K5-Cre mice GSE17345: Analysis of temporal mRNA expression changes in cultured keratinocytes from Casp-8F/–K5-Cre and Casp-8F/+K5-Cre mice Refer to individual Series

OTHER RELATED OMICS DATASETS IN: PRJNA123609PRJNA119089PRJNA123607

ORGANISM(S): Mus Musculus

SUBMITTER: Oliver Dittrich-Breiholz  

PROVIDER: E-GEOD-17365 | ArrayExpress | 2009-07-29

SECONDARY ACCESSION(S): GSE17365PRJNA119089

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-17365.README.txt Txt
E-GEOD-17365.idf.txt Idf
E-GEOD-17365.processed.1.zip Processed
E-GEOD-17365.raw.1.zip Raw
E-GEOD-17365.sdrf.txt Txt
Items per page:
1 - 5 of 5
altmetric image

Publications

Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease.

Kovalenko Andrew A   Kim Jin-Chul JC   Kang Tae-Bong TB   Rajput Akhil A   Bogdanov Konstantin K   Dittrich-Breiholz Oliver O   Kracht Michael M   Brenner Ori O   Wallach David D  

The Journal of experimental medicine 20090831 10


Expression of enzymatically inactive caspase-8, or deletion of caspase-8 from basal epidermal keratinocytes, triggers chronic skin inflammation in mice. Unlike similar inflammation resulting from arrest of nuclear factor kappaB activation in the epidermal cells, the effect induced by caspase-8 deficiency did not depend on TNF, IL-1, dermal macrophage function, or expression of the toll-like receptor adapter proteins MyD88 or TRIF. Both interferon regulatory factor (IRF) 3 and TANK-binding kinase  ...[more]

Similar Datasets

| E-GEOD-17365 | BioStudies
2009-07-29 | E-GEOD-17345 | ArrayExpress
2009-07-29 | E-GEOD-17344 | ArrayExpress
| E-GEOD-17344 | BioStudies
| E-GEOD-17345 | BioStudies
2009-07-29 | GSE17344 | GEO
2009-07-29 | GSE17345 | GEO
| PRJNA119089 | ENA
| PRJNA123609 | ENA
| PRJNA123607 | ENA