Transcriptomics,Multiomics

Dataset Information

44

Transcription profiling of human multiple myeloma cells ( MM1.S) cells with control or beta-catenin knockdown.


ABSTRACT: MM1.S cells stably transduced with control or beta-catenin shRNA were established. Total RNA was isolated from 5x 10^6 cells of each in triplicate. Experiment Overall Design: Comparative gene expression profiling in multiple myeloma.

REANALYSED by: E-GEOD-17385

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Daniel Ruben Carrasco   

PROVIDER: E-GEOD-17385 | ArrayExpress | 2015-09-04

SECONDARY ACCESSION(S): GSE17385PRJNA118817

REPOSITORIES: GEO, ArrayExpress

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Publications


Multiple myeloma (MM) is a cancer of plasma cells with complex molecular characteristics that evolves from monoclonal gammopathy of undetermined significance, a highly prevalent premalignant condition. MM is the second most frequent hematologic cancer in the United States, and it remains incurable, thereby highlighting the need for new therapeutic approaches, particularly those targeting common molecular pathways involved in disease progression and maintenance, shared across different MM subtype  ...[more]

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