Dataset Information


Transcriptional profiling of intestinal tissue samples from germ-free and conventionally raised mice which are either wild-type or Myd88-/-

ABSTRACT: Whole-transcriptome survey of gene expression differences between germ-free (GF) and conventionally raised (CONV-R) mice. To assess the role of toll-like receptor signalling, both wild-type and Myd88 -/- mice were used. Four different tissues were harvested from 20 mice (5 WT CONV-R, 5 Myd88 -/- CONV-R, 4 WT GF, 6 Myd88 -/- GF) and expression profiles were determines using the Affymetrix Mouse Gene 1.0ST platform. 77 samples remained after quality control.


ORGANISM(S): Mus musculus  

SUBMITTER: E Larsson   C Reigstad  F Bäckhed  Erik Larsson 

PROVIDER: E-GEOD-17438 | ArrayExpress | 2011-12-08



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Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88.

Larsson Erik E   Tremaroli Valentina V   Lee Ying Shiuan YS   Koren Omry O   Nookaew Intawat I   Fricker Ashwana A   Nielsen Jens J   Ley Ruth E RE   Bäckhed Fredrik F  

Gut 20111123 8

BACKGROUND: The gut microbiota has profound effects on host physiology but local host-microbial interactions in the gut are only poorly characterised and are likely to vary from the sparsely colonised duodenum to the densely colonised colon. Microorganisms are recognised by pattern recognition receptors such as Toll-like receptors, which signal through the adaptor molecule MyD88. METHODS: To identify host responses induced by gut microbiota along the length of the gut and whether these required  ...[more]

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