Transcriptomics

Dataset Information

7

Gene Expression in Frontal Cortex in Major Depression and HIV


ABSTRACT: Major depressive disorder (MDD) is a clinically defined entity with little understanding as to the underlying pathological substrate. Biologically, MDD is characterized by disruption of neurotransmitters, especially serotonin and noradrenaline, which are the main targets of antidepressants. We previously demonstrated significant reduction of glial cell number in the cingulate and dorsolateral prefrontal cortical regions. Unfortunately, individuals living with HIV still have very high rates of MDD, despite the fact that mortality rates have fallen sharply with effective antiretroviral treatment. It is possible that in this treatment era, living with chronic HIV infection may result in long-term neuropathological changes that predispose to MDD. For example, it is known that HIV is associated with a range of inflammatory pathologies, neuronal loss, and dendrite-synaptic damage. In HIV, these neurodegenerative changes have been linked to neurocognitive impairments, however it is also possible that these changes potentiate MDD. In the current study, we sought to determine whether there are changes in gene expression in the MDD brain in the frontal cortex in HIV-context. We identify a large number of genes dysregulated at p<0.05 significance. Retrospective gene expression analysis of autopsy brain tissue. Four HIV/MDD subjects are identified and age-matched HIV patients without neuropsychiatric conditions are compared as controls.

ORGANISM(S): Homo sapiens  

SUBMITTER: Timothy B Nguyen   Erick T Tatro  Shahid Salaria  Gursharan Chana  Cristian L Achim  Eliezer Masliah  Erick R Scott  Ian P Everall 

PROVIDER: E-GEOD-17440 | ArrayExpress | 2010-02-01

SECONDARY ACCESSION(S): GSE17440PRJNA123617

REPOSITORIES: GEO, ArrayExpress

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Publications

Evidence for Alteration of Gene Regulatory Networks through MicroRNAs of the HIV-infected brain: novel analysis of retrospective cases.

Tatro Erick T ET   Scott Erick R ER   Nguyen Timothy B TB   Salaria Shahid S   Banerjee Sugato S   Moore David J DJ   Masliah Eliezer E   Achim Cristian L CL   Everall Ian P IP  

PloS one 20100426 4


HIV infection disturbs the central nervous system (CNS) through inflammation and glial activation. Evidence suggests roles for microRNA (miRNA) in host defense and neuronal homeostasis, though little is known about miRNAs' role in HIV CNS infection. MiRNAs are non-coding RNAs that regulate gene translation through post-transcriptional mechanisms. Messenger-RNA profiling alone is insufficient to elucidate the dynamic dance of molecular expression of the genome. We sought to clarify RNA alteration  ...[more]

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