Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA118875
SUBMITTER: S Pfister Simone Bork H Witt S Bork AD Ho B Korn P Horn W Wagner
PROVIDER: E-GEOD-17448 | ArrayExpress | 2010-05-14
SECONDARY ACCESSION(S): GSE17448PRJNA118875
REPOSITORIES: GEO, ArrayExpress
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E-GEOD-17448.README.txt | Txt | |||
E-GEOD-17448.idf.txt | Idf | |||
E-GEOD-17448.processed.1.zip | Processed | |||
E-GEOD-17448.raw.1.zip | Raw | |||
E-GEOD-17448.sdrf.txt | Txt |
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Aging cell 20091106 1
Within 2-3 months of in vitro culture-expansion, mesenchymal stromal cells (MSC) undergo replicative senescence characterized by cell enlargement, loss of differentiation potential and ultimate growth arrest. In this study, we have analyzed DNA methylation changes upon long-term culture of MSC by using the HumanMethylation27 BeadChip microarray assessing 27,578 unique CpG sites. Furthermore, we have compared MSC from young and elderly donors. Overall, methylation patterns were maintained through ...[more]