Transcriptomics

Dataset Information

3

Hematopoietic Transcriptional Comparison of HSC from B10.BR/JRep and B10.BR/J (drifted) mice


ABSTRACT: Divergence has occured between the B10.BR-H2k H2-T18a/SgSnJJrep and B10.BR-H2k H2-T18a/SgSnJ (drifted) mouse strains, resulting in altered antigenic recognition and differential bone marrow engraftment capability. The microarray data demonstrate that the transcriptional profile of genes associated with hematopoiesis differs between lineage negative (as a marker for hematopoietic stem cells) bone marrow cells isolated from the B10.BR-H2k H2-T18a/SgSnJJrep and B10.BR-H2k H2-T18a/SgSnJ (drifted) mouse strains. Bone marrow cells from ten male mice of each strain, aged 10-12 weeks, were harvested. One pooled sample was analyzed for each strain.

ORGANISM(S): Mus musculus  

SUBMITTER: Stacey L Fanning   Thea M Friedman  Michael Y Appel  Michael Appel  Stephanie A Berger  Robert Korngold 

PROVIDER: E-GEOD-17471 | ArrayExpress | 2009-09-15

SECONDARY ACCESSION(S): GSE17471PRJNA118713

REPOSITORIES: GEO, ArrayExpress

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Publications

The immunological impact of genetic drift in the B10.BR congenic inbred mouse strain.

Fanning Stacey L SL   Appel Michael Y MY   Berger Stephanie A SA   Korngold Robert R   Friedman Thea M TM  

Journal of immunology (Baltimore, Md. : 1950) 20090914 7


The MHC-matched, minor histocompatibility Ag (miHA)-mismatched B10.BR-->CBA strain combination has been used to elucidate the immunobiology of graft-vs-host disease (GVHD) following allogeneic bone marrow transplantation. Studies conducted in the 1980s had established that B10.BR CD8+ T cells were capable of mediating GVHD in the absence of CD4+ T cells, and that CD4+ T cells were unable to induce lethal disease. In more recent studies with this GVHD model, we detected etiological discrepancies  ...[more]

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