Transcriptomics

Dataset Information

10

Transcription profiling of C. elegans long luved daf-2 mutants for the insulin/IGF-1 receptor. daf-2(e1370) and daf-2(m577) alleles each examined as single and as double mutations with the daf-16(df50) reveals insights into longevity


ABSTRACT: Analysis of gene expression in long-lived daf-2 mutants for the insulin/IGF-1 receptor. daf-2(e1370) and daf-2(m577) alleles each examined as single and as double mutations with the daf-16(df50) allele. DAF-2 regulates DAF-16, a transcription factor. Results provide insight into longevity.

ORGANISM(S): Caenorhabditis elegans  

SUBMITTER: Joshua J. McElwee  

PROVIDER: E-GEOD-1762 | ArrayExpress | 2007-07-05

SECONDARY ACCESSION(S): GDS770GSE1762PRJNA90521

REPOSITORIES: GEO, ArrayExpress

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Publications

Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance.

McElwee Joshua J JJ   Schuster Eugene E   Blanc Eric E   Thomas James H JH   Gems David D  

The Journal of biological chemistry 20040811 43


In the nematode Caenorhabditis elegans, formation of the long-lived dauer larva and adult aging are both controlled by insulin/insulin-like growth factor-1 signaling. Potentially, increased adult life span in daf-2 insulin/insulin-like growth factor-1 receptor mutants results from mis-expression in the adult of a dauer larva longevity program. By using oligonucleotide microarray analysis, we identified a dauer transcriptional signature in daf-2 mutant adults. By means of a nonbiased statistical  ...[more]

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