Transcriptomics

Dataset Information

5

Transcription profiling of human muscle biopsies from Duchenne muscular dystrophy subjects treated with oxandrolone


ABSTRACT: Three subjects with Duchenne muscular dystrophy (8.3, 10.4, and 16.7 years old) were studied. Baseline studies included stable isotope infusion followed by gastrocnemius muscle biopsy to determine myosin heavy chain synthesis rates. RNA was isolated from the muscle biopsy as well. The subjects were then treated for 3 months with oxandrolone (a synthetic anabolic steroid, 0.1 mg/kg/day) and the studies repeated.

ORGANISM(S): Homo sapiens  

DISEASE(S): Duchenne Muscular Dystrophy

SUBMITTER: Robert C. Olney  

PROVIDER: E-GEOD-1764 | ArrayExpress | 2007-08-25

SECONDARY ACCESSION(S): GDS1333GDS1334GSE1764PRJNA90307

REPOSITORIES: GEO, ArrayExpress

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Publications

Oxandrolone enhances skeletal muscle myosin synthesis and alters global gene expression profile in Duchenne muscular dystrophy.

Balagopal Prabhakaran P   Olney Robert R   Darmaun Dominique D   Mougey Edward E   Dokler Maryann M   Sieck Gary G   Hammond David D  

American journal of physiology. Endocrinology and metabolism 20051101 3


Earlier studies have shown that the progressive, unrelenting muscle loss associated with Duchenne muscular dystrophy (DMD) involves an imbalance between the rates of synthesis and degradation of muscle proteins. Although previous studies have suggested that oxandrolone may be beneficial in DMD, the mechanism of action of oxandrolone on muscle in DMD remains unclear. To address these issues, we combined stable isotope studies and gene expression analysis to measure the fractional synthesis rate o  ...[more]

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