Dataset Information


Comparative Genomic Analysis of PhoP Regulon in S. Typhi and S. Typhimurium

ABSTRACT: Transcriptional profiling of three sequenced S. enterica strains: S. Typhimurium LT2, S. Typhi CT18, and S. Typhi Ty2 in PhoP-inducing and non-inducing conditions in vitro, and compared these results to profiles of phoP-/Q- mutants derived from S. Typhimurium LT2 and S. Typhi Ty2. Two-condition experiment: Each strain above was grown in PhoP-inducing (Low Magnesium concentration) and PhoP non-inducing conditions (High Magnesium concentration) with 1 dye reversal.

SUBMITTER: Lauren Lebrun   Richelle C. Charles  Jason B Harris  Tanya Logvinenko  Stephen Calderwood  Firdausi Qadri  Edward T Ryan  Richelle Charles  Alaullah Sheikh  Abdullah Tarique 

PROVIDER: E-GEOD-17670 | ArrayExpress | 2010-05-06



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BACKGROUND:S. Typhi, a human-restricted Salmonella enterica serovar, causes a systemic intracellular infection in humans (typhoid fever). In comparison, S. Typhimurium causes gastroenteritis in humans, but causes a systemic typhoidal illness in mice. The PhoP regulon is a well studied two component (PhoP/Q) coordinately regulated network of genes whose expression is required for intracellular survival of S. enterica. METHODOLOGY/PRINCIPAL FINDINGS:Using high performance liquid chromatography mas  ...[more]

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